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Selection from Decision-Making Practice – 20/2026

Pharmeca a.s. 23. 09. 2026

The State Institute for Drug Control (the Institute) initiated ex officio proceedings to change the maximum price of an orphan medicinal product pursuant to Section 39da(10) of Act No. 48/1997 Coll., on Public Health Insurance. According to the provision in force on the date the proceedings were initiated:
“No later than 3 years from the date on which the decision establishing the amount and conditions of reimbursement of an orphan medicinal product becomes enforceable, the Institute shall initiate ex officio administrative proceedings to change the maximum price pursuant to Section 39i. Sections 39l and 39p shall apply mutatis mutandis.”

The marketing authorisation holder (MAH) argued that the proceedings should not have been initiated “automatically”, but only “where necessary”. According to the MAH, the Institute should have assessed whether the proceedings served a meaningful purpose and would result in actual savings; otherwise, the proceedings should have been discontinued.
The Institute stated that the law imposes an unconditional obligation to initiate proceedings to change the maximum price within 3 years of the date on which the orphan reimbursement decision becomes enforceable. According to the Institute, the condition “where necessary” does not apply to the initiation of proceedings to change the maximum price of an orphan medicinal product itself. In this case, the three-year requirement for initiating the proceedings was therefore met.

The MAH further argued that the statutory requirement of annual savings of CZK 30 million, applicable to the review proceedings referred to in Section 39da(10), had not been demonstrated. In the MAH’s view, the Institute should have demonstrated the expected savings to the public health insurance system; without doing so, the proceedings were unlawful or not subject to proper review.
The Institute maintained that demonstrating such savings is not a statutory requirement for this type of proceeding. The requirement that the relevant provisions apply mutatis mutandis does not mean that the conditions governing the initiation of a reimbursement review are transferred to these individual proceedings concerning a change in the maximum price of an orphan medicinal product. The purpose of these proceedings is not to generate reimbursement savings, but to change the maximum price.

The MAH also argued that the maximum price of the medicinal product concerned had already been changed previously and that there was therefore no justification for further ex officio proceedings.
The Institute stated that the earlier proceedings cannot be regarded as fulfilling the obligation under Section 39da(10), as the law requires these specific proceedings to be initiated no later than 3 years after the orphan reimbursement decision becomes enforceable, irrespective of whether another change in the maximum price has taken place in the meantime.

The Institute rejected all the objections and issued a decision in the matter, against which the MAH filed an appeal.


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Articles on decision-making practice are based on publicly available texts from the decisions of the Ministry of Health of the Czech Republic and the State Institute for Drug Control (SÚKL).

A continuously updated overview of decisions issued by SÚKL and the Ministry of Health in the field of pricing and reimbursement is available on the Pharmeca a.s. website.

The English translation was prepared using the latest available ChatGPT model.

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